Composition and How It Works

• Losartan (50 mg): An angiotensin II receptor blocker (ARB) that relaxes blood vessels, increases sodium excretion, and lowers aldosterone production.
• Amlodipine (5 mg): A calcium channel blocker (CCB) that widens and relaxes blood vessels to reduce blood pressure.
• Hydrochlorothiazide (12.5 mg): A thiazide diuretic that promotes urination to eliminate excess water and salt, lowering blood volume and blood pressure.

The combination offers comprehensive blood pressure control, particularly beneficial for patients with resistant hypertension or additional risk factors like diabetes or cardiovascular disease Primary Uses

• Treatment of high blood pressure (hypertension).
• Reducing the risk of stroke, heart attack, and kidney problems associated with hypertension.
• Managing hypertension in patients unresponsive to single medications or with diabetes.

Dosage and Administration

• Typically taken once daily, at the same time each day for maximum effectiveness.
• Can be taken with or without food, but consistency is recommended.
• Swallow tablets whole, do not crush or chew.
• Missed dose: Take as soon as remembered unless it is nearly time for the next dose. Do not double doses .
• Overdose: May cause dizziness, low blood pressure, fainting, or excessive urination. Seek medical attention immediately if suspected.

Common Side Effects

Dizziness, headache, drowsiness, lightheadedness, stomach pain, nausea, diarrhea, or muscle weakness ankle swelling, chest tightness, or chills.

Most side effects are mild and tend to resolve with time but seek medical attention for severe reactions like allergic symptoms, reduced urination, swelling, or very low blood pressure.

Precautions and Warnings

• Pregnancy & Breastfeeding: Not recommended; consult your doctor if pregnant or breastfeeding due to potential harm to the baby.
• Alcohol: Avoid, as it may amplify dizziness and low blood pressure.
• Kidney and Liver Function: Regular monitoring may be required; avoid in severe kidney or liver disease.
• Hyperkalemia: Avoid potassium-rich foods or supplements, as blood potassium levels may rise.
• Driving/Operating Machines: Exercise caution due to possible dizziness or drowsiness.
• Medical Conditions: Inform your doctor if you have diabetes, coronary artery disease, heart failure, hypotension, or a history of kidney problems.